COMPOUND A398, A NOVEL PODOPHYLLOTOXIN ANALOGUE: CYTOTOXICITY AND INDUCTION OF APOPTOSIS IN HUMAN LEUKEMIA CELLS.

Compound A398, a novel podophyllotoxin analogue: cytotoxicity and induction of apoptosis in human leukemia cells.

Despite advances in oncology research, cancer is one of the leading causes of death worldwide.Thus, there is a demand for the development of more selective and effective antitumor agents.This study showed that A398, a novel podophyllotoxin analogue, was cytotoxic to the HT-29, MCF-7, MOLT-4 and HL-60 tumor cell lines, being less active in Bluetooth

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Identification and Characterization of Differentially Expressed Genes in Inferior and Superior Spikelets of Rice Cultivars with Contrasting Panicle-Compactness and Grain-Filling Properties.

Breeding programs for increasing spikelet number in rice have resulted in compactness of the panicle, accompanied by poor grain filling in inferior spikelets.Although the inefficient utilization of assimilate has been indicated as responsible for this poor grain filling, the underlying cause remains elusive.The current study utilized the suppressio

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Activity of Nitric Oxide Is Dependent On, But Is Partially Required for Function of, Salicylic Acid in the Signaling Pathway in Tobacco Systemic Acquired Resistance

When tobacco plants were treated by injection with nitric oxide (NO)-releasing compounds, the sizes of lesions caused by Tobacco mosaic virus (TMV) on the treated leaves and on upper nontreated leaves were significantly reduced.The reduction in TMV lesion size was caused by NO released from the NO-releasing compounds; the byproduct formed after rel

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